“HFE – the rusty cog” is a “DNA dot-to-dot” digital drawing made using the haemochromatosis (HFE) gene DNA sequence. It is made from a single line that links small dots, the colour of which indicates the DNA base (A = green, C = blue, G = yellow, T = red). The line joining the bases changes colour and creates a drawing of a rusty cog in industrial machinery. The positions of the bases that are commonly mutated in haemochromatosis (p.C282Y and p.H63D) are indicated with circles surrounding the affected bases. The "the rusty cog" is a metaphor for haemochromatosis - the human body is like a machine, made from lots of moving parts that all need to function for the whole thing to work. When HFE does not function, iron builds up in the form of rust, preventing the machine from working properly. To find out more visit www.dansdna.com.

Dimensions: 52.6cm x 54.1 cm including frame.